49ers Face Setback as Star TE George Kittle Sidelined by Hamstring Injury

49ers tight end George Kittle misses practice due to a hamstring issue, raising concerns about his status.

The San Francisco 49ers face another blow on offense after tight end George Kittle missed practice Thursday with what ESPN and NFL Network reported as a hamstring strain.

The 49ers may not have Kittle available for Week 3 when they face the Los Angeles Rams on Sunday.

Kittle, a five-time Pro Bowler and four-time All-Pro (including two first-team selections), had 11 receptions for 116 yards and a touchdown in the Niners’ first two games in 2024.

The 30-year-old has played in 100 games (92 starts) since beginning his NFL career with San Francisco as a fifth-round pick in the 2017 draft, hauling in 471 receptions for 6,390 yards and 38 touchdowns.

The 49ers already have two explosive weapons on offense: running back Christian McCaffrey (calf/Achilles), who is on injured reserve, and wide receiver Deebo Samuel (torn calf), who is expected to miss a couple of weeks.

Cornerback Charvarius Ward (hamstring/knee) also missed Thursday’s practice.

With Kittle potentially sidelined, the spotlight now shifts to how the Niners will adapt their game plan to confront the formidable Rams.

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