Patriots vs. 49ers Showdown: Predictions, Odds, Injuries, and Key Player Insights

Get the latest insights on the Patriots vs. 49ers matchup, including expert picks, odds, player news, and injury updates.

Despite battling several key injuries, the plucky 49ers (1-2) positioned themselves for a triumphant finish last Sunday against the Rams. They were cruising with a 24-14 lead midway through the fourth quarter. But alas, they were outscored 13-0 in the last 6:15, falling short 27-24. Did they lose because they gassed out or merely let their guard down? If it’s the latter, then there’s hope for improvement. This week, Kyle Shanahan’s troops are bracing for another battle as Deebo Samuel and Christian McCaffrey remain sidelined, and now, Brock Purdy is also nursing an injury.

For the Patriots, it’s not about injuries anymore. After a split start to the season, New England barely showed up in their matchup against the Jets, evident in just two series. It became clear last Thursday that the Patriots (1-2) were set for a drubbing, and they indeed got walloped 24-3. The question arising now is: was it a collapse in effort or a glaring lack of talent?

The Showdown: Patriots vs. 49ers

Two **teams seeking momentum** in their respective divisions will clash at Levi’s Stadium this Sunday afternoon. The Patriots and the 49ers are set for an electrifying matchup.

Let’s delve into this enticing duel and sweat over the details:

NBC Sports has everything you need to stay on top of the game, from kickoff times to team odds, key player updates, and expert predictions. Don’t miss a beat!

Listen to the Bet the Edge podcast with Jay Croucher and Drew Dinsick for sharp insights, market analysis, and statistical data to help you bet smarter. Whether you’re eyeing spreads and totals, futures markets, or player props, their expert tips will give you the extra edge.

Game Details: Patriots vs. 49ers

  • Date: Sunday, September 29, 2024
  • Time: 4:05 PM EST
  • Site: Levi’s Stadium
  • City: Santa Clara, CA
  • TV/Streaming: FOX

Interested in the rest of the NFL action this week? NBC Sports has you covered with all the game schedules, venues, and TV info you need!

Game Odds: New England vs. San Francisco

As of Thursday evening, the latest odds from DraftKings:

  • Moneyline: New England Patriots (+390), San Francisco 49ers (-520)
  • Spread: 49ers -10
  • Total: 40.5

The game opened with San Francisco as a 10.5-point favorite and a Game Total of 40, with minimal changes since then.

NBC Sports Bets: Expert Picks

Vaughn Dalzell (@VmoneySports) is all in on the 49ers:

“What’s tougher than coming off a 24-3 drubbing to your divisional rivals, the New York Jets? Traveling across the country to take on the 49ers’ defense that’s hungry for redemption after two losses. Jacoby Brissett will need more than a few Hail Marys to cover this spread. I’m taking the Niners laying the 10.”

Team Stats and Betting Trends

  • The 49ers are 3-7 ATS in their last 10 games as home favorites
  • Dating back to last season, the Patriots are 12-8 to the UNDER
  • This marks only the 5th time since 2000 that the Patriots are double-digit underdogs
  • San Francisco leads the all-time series 9-5 and is 4-2 at home against New England
  • New England ranks as the second-lowest scoring offense in the league with the worst passing game

Rotoworld has got all your NFL betting needs covered with game predictions, player props, futures, and trends!

Quarterback Matchup: Patriots vs. 49ers

  • New England: Jacoby Brissett – managed to throw just 12 completions for a measly 98 yards last weekend against the Jets, and was sacked five times.
  • San Francisco: Brock Purdy – has delivered a strong performance, completing 72.6% of his passes for 842 yards, 4 TDs, and just 1 INT this season. Purdy threw 3 TDs last week in the loss to the Rams.

Player News & Injury Updates

  • New England TE Hunter Henry (ankle) was limited in Wednesday’s practice and is questionable for Sunday.
  • New England CB Christian Gonzalez (undisclosed) is also questionable.
  • New England LG Sidy Sow (ankle) practiced this week but remains questionable.
  • San Francisco WR Deebo Samuel (calf) is doubtful for Sunday.
  • San Francisco TE George Kittle (hamstring) is questionable.
  • San Francisco OT Trent Williams (undisclosed) is questionable as well.

Stay tuned with our experts for all the latest updates and insider insights!

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