Week 10 College Football Predictions: Expert Picks and Key Matchup Insights

Week 10 CFB picks highlight key matchups, expert insights, and grid projections for Saturday's games.

As we dive into Week 10 of the college football season, excitement is in the air! Two top-10 teams are set to face significant road challenges, and the stakes couldn’t be higher. The matchups promise thrilling action, and fans are eager to see how these powerhouse teams perform under pressure.

Ohio State vs. Penn State: A Clash of Titans

No. 4 Ohio State is heading to Beaver Stadium for a highly anticipated showdown against No. 3 Penn State. Kickoff is scheduled for 12 p.m. ET on the Big Noon Kickoff Game. The Buckeyes are currently favored by 3.5 points, and the PoolGenius college football data grid gives them a 52.2% chance of victory. Will this be the year the Nittany Lions finally break their losing streak against Ohio State, which dates back to 2016? The atmosphere will be electric, and both teams know what’s at stake.

Texas A&M’s Prime-Time Challenge

Meanwhile, No. 10 Texas A&M faces a tough road test at South Carolina, kicking off at 7:30 p.m. on ABC. The Aggies are given a 53.7% chance to win, according to the PoolGenius data grid. With a strong performance needed to maintain their momentum in SEC play, Texas A&M will have to navigate a challenging environment against a determined Gamecocks squad. Can they rise to the occasion?

PoolGenius Insights: Your Winning Strategy

Throughout the 2024 season, Sporting News is teaming up with PoolGenius to deliver top-notch pool strategy tips, expert quick picks, and up-to-date data grids—all aimed at helping you succeed. The PoolGenius college football data grid not only predicts winners for every game but also highlights discrepancies between its model and the betting public. This gives you the chance to uncover hidden opportunities across the entire schedule.

Key Matchups to Watch

Friday, Nov. 1

  • San Diego State at No. 15 Boise State (-23.5) (8 p.m., FS1)

For first-year coach Sean Lewis, a trip to Boise State will be a tough challenge. The Aztecs have shown resilience, splitting their last four games, all decided by a single score. With the Broncos allowing 159.6 rushing yards per game, expect Ashton Jeanty to have a significant impact. While Boise State is 1-2 against the spread as a double-digit favorite this season, they should secure the win, but the Aztecs might sneak in a late cover.

Pick: Boise State wins 35-14 but FAILS TO COVER the spread.

PoolGenius pick: Boise State

Saturday, Nov. 2

  • No. 4 Ohio State (-4) at No. 3 Penn State (12 p.m., Fox)

Ohio State’s offensive line has raised concerns after a less-than-dominant Week 8. The Nittany Lions boast a defense that matches up well against the Buckeyes. If quarterback Drew Allar’s status remains uncertain, backup Beau Pribula will need to step up. Meanwhile, Ohio State’s defense is formidable, with 13 tackles for loss last week. Expect a competitive game, but can Jeremiah Smith shine as the best player on the field?

Pick: Ohio State wins 27-17 and COVERS the spread.

PoolGenius pick: Ohio State

  • Duke at No. 5 Miami, Fla. (-20) (12 p.m., ABC)

The Blue Devils have been competitive under first-year coach Manny Diaz, ranking second in the ACC in scoring defense. However, Miami’s Cam Ward presents a different challenge. The Hurricanes are expected to secure a win, but will they cover the spread?

Pick: Miami wins 38-21 but FAILS TO COVER the spread.

PoolGenius pick: Miami

  • No. 19 Ole Miss (-6.5) at Arkansas (12 p.m. ESPN)

This SEC matchup is tricky for the Rebels, who have struggled to cover as favorites recently. With Ole Miss leading the FBS in scoring defense, they’ll need to rely on their strengths against a resilient Arkansas squad.

Pick: Ole Miss wins 27-20 and COVERS the spread.

PoolGenius pick: Ole Miss

  • Minnesota (-2.5) at No. 24 Illinois (12 p.m., FS1)

Illinois as an underdog? The Gophers have been on a winning streak, but the Illini have a history of success in this matchup. Will they continue their dominance?

Pick: Illinois wins 21-19 in an UPSET.

PoolGenius pick: Minnesota

Evening Showdowns

  • No. 2 Georgia (-16) vs. Florida (3:30 p.m., ABC)

Georgia has been impressive in their recent matchups, but Florida will be looking to make a statement. Can the Gators keep it close?

Pick: Georgia wins 34-17 and COVERS the spread.

PoolGenius pick: Georgia

  • No. 10 Texas A&M (-3.5) at South Carolina (7:30 p.m., ABC)

With uncertainty at quarterback, Texas A&M faces a challenge against South Carolina. However, their historical success against the Gamecocks gives them an edge.

Pick: Texas A&M wins 28-21 and COVERS the spread.

PoolGenius pick: Texas A&M

Final Thoughts

As these teams gear up for crucial matchups, fans can expect thrilling action and intense competition. Whether it’s Ohio State trying to extend their dominance or Texas A&M battling on the road, the drama of college football is on full display. Keep an eye on these games, as they could shape the landscape of the season!

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