No. 4 Ohio State is set to clash with No. 3 Penn State in what promises to be a thrilling fourth top-five showdown of the 2024 college football season. This highly anticipated matchup headlines the Week 10 schedule, and fans are buzzing with excitement. The Buckeyes, boasting a record of 6-1, are determined to stave off a second conference loss, while the unbeaten Nittany Lions (7-0) are eager to see their star quarterback, Drew Allar, return to the field for this Big Noon Kickoff at 12 p.m. ET on Fox. Historically, this series has been a tough nut to crack for Penn State, as they’ve dropped nine of the last ten encounters against Ohio State.
But that’s not all! Another undefeated squad from the Keystone State will take center stage under the lights. No. 18 Pitt (7-0) is gearing up to face No. 20 SMU (7-1) in a pivotal ACC showdown. The weekend also promises to deliver a classic rivalry as No. 2 Georgia takes on Florida, alongside a modern Big Ten battle featuring No. 1 Oregon squaring off against Michigan. Will the Gators or Wolverines pull off an upset and shake up the landscape of college football this weekend?
Week 10 Picks Against the Spread
Friday, Nov. 1
- San Diego State at No. 15 Boise State (-23.5) (8 p.m., FS1)
The Aztecs are embarking on a challenging journey to Boise State, where first-year coach Sean Lewis faces a tough test. With a mixed bag of results in their last four games—all decided by a single score—San Diego State is hoping to find their footing. They’ve struggled against the run, allowing 159.6 rushing yards per game, which could spell trouble against the Broncos’ Ashton Jeanty. Despite Boise State’s struggles as a double-digit favorite this season, they’re poised to win, but the Aztecs will sneak in a late cover thanks to a touchdown run by Marquez Cooper.
Pick: Boise State wins 35-14 but FAILS TO COVER the spread.
Saturday, Nov. 2
- No. 4 Ohio State (-4) at No. 3 Penn State (12 p.m., Fox)
The Buckeyes are coming off a less-than-stellar performance in Week 8, raising eyebrows about their offensive line’s ability to handle Penn State’s formidable defense. With Allar’s status still uncertain, the Nittany Lions could lean on experienced backup Beau Pribula. Ohio State’s defense, fresh off a week with 13 tackles for loss, will be a force to reckon with. Expect a battle reminiscent of last season’s nail-biter, where the spotlight shines on freshman sensation Jeremiah Smith. Will Howard and Smith connect for a couple of touchdowns, leading Ohio State to their eighth consecutive victory in this storied rivalry?
Pick: Ohio State wins 27-17 and COVERS the spread.
- Duke at No. 5 Miami, Fla. (-20) (12 p.m., ABC)
The Blue Devils have shown grit this season under first-year coach Manny Diaz, a familiar face in Miami. With a scoring defense that ranks second in the ACC, they’ve proven they can slow down high-octane offenses. However, the Hurricanes, led by the electric Cam Ward, are a different beast altogether when they avoid turnovers.
Pick: Miami wins 38-21 but FAILS TO COVER the spread.
- No. 19 Ole Miss (-6.5) at Arkansas (12 p.m. ESPN)
The SEC is notorious for its unpredictability, and this matchup is no exception. Ole Miss has struggled to cover as a favorite lately, but with a scoring defense leading the FBS, they’re still a formidable opponent. Arkansas has been a tough nut to crack as an underdog, and with five of their last eight meetings decided by a razor-thin margin, expect fireworks.
Pick: Ole Miss wins 27-20 and COVERS the spread.
- Minnesota (-2.5) at No. 24 Illinois (12 p.m., FS1)
The Gophers are riding a three-game winning streak, but Illinois has been a thorn in their side historically. With both teams boasting efficient quarterbacks, this matchup promises to be a nail-biter.
Pick: Illinois wins 21-19 in an UPSET.
- No. 2 Georgia (-16) vs. Florida (3:30 p.m., ABC)
In this fierce rivalry, the Bulldogs are looking to make a statement after a bye week. Georgia has dominated the recent meetings, but the Gators are hungry for an upset. Expect a battle that could come down to the wire.
Pick: Georgia wins 34-17 and COVERS the spread.
- Texas Tech at No. 11 Iowa State (-14.5) (3:30 p.m., ESPN)
Iowa State returns from a bye week, ready to unleash their high-powered offense against a struggling Texas Tech defense. With the Cyclones leading the nation in passing efficiency, they’re poised for a decisive victory.
Pick: Iowa State wins 34-20 but FAILS TO COVER the spread.
- No. 13 Indiana (-7) at Michigan State (3:30 p.m., Peacock)
The Hoosiers are riding high, but will they have their star quarterback back? Michigan State is reeling from a tough loss, and this matchup could be a turning point for both teams.
Pick: Indiana wins 31-19 and COVERS the spread.
- No. 17 Kansas State (-13) at Houston (3:30 p.m., Fox)
Kansas State is on the hunt for a Big 12 title, and their rushing attack is a force to be reckoned with. Expect the Cougars to put up a fight, but the Wildcats are too strong.
Pick: Kansas State wins 41-16 and COVERS the spread.
- No. 1 Oregon (-14.5) at Michigan (3:30 p.m., CBS)
Oregon is looking to make a statement with a dominating performance at the Big House. With a defense that has been stifling, the Ducks are ready to prove they belong at the top.
Pick: Oregon wins 30-16 but FAILS TO COVER the spread.
- No. 10 Texas A&M (-3.5) at South Carolina (7:30 p.m., ABC)
The Aggies are unbeaten in SEC play, but uncertainty at quarterback could pose a challenge. South Carolina has shown they can compete, but can they break the Aggies’ winning streak?
Pick: Texas A&M wins 28-21 and COVERS the spread.
- Louisville at No. 11 Clemson (-11) (7:30 p.m., ESPN)
Clemson is coming off a bye week, and their offense is firing on all cylinders. The Cardinals have struggled as underdogs, and this matchup could be a tough test for them.
Pick: Clemson wins 34-24 and COVERS the spread.
- Kentucky at No. 7 Tennessee (-16) (7:45 p.m., SEC Network)
Tennessee is looking to bounce back after a bye week, and they have the momentum in this rivalry matchup. Expect a fierce battle as both teams look to assert their dominance.
Pick: Tennessee wins 31-14 and COVERS the spread.
- No. 18 Pitt at No. 20 SMU (-7) (8 p.m., ACC Network)
This matchup could be a game-changer in the ACC race. With both teams boasting top-notch run defenses, it will come down to which quarterback can rise to the occasion.
Pick: SMU wins 29-28 but FAILS TO COVER the spread.
As the college football landscape continues to shift, Week 10 promises to deliver drama, excitement, and perhaps a few surprises. Buckle up, folks—this is going to be one wild ride!
