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Week 12 College Football Predictions: Expert Insights and Game Projections

Week 12 college football picks highlight key matchups, expert insights, and grid projections for Saturday's games.

Where is the best chance for an upset that could shake up the College Football Playoff picture in Week 12? According to the PoolGenius college football data grid, you might want to stay up late to find out. Kansas is set to travel to No. 7 BYU for a thrilling matchup at 10:15 p.m. ET on Saturday. The Cougars, boasting an impressive 9-0 record this season, are given a 58.3% chance to win. Could the Jayhawks pull off another surprise that rattles the Big 12?

Key Matchups to Watch

One of the most anticipated games in Week 12 features No. 6 Tennessee squaring off against No. 11 Georgia in a critical SEC showdown. The Bulldogs are favored with a 75% chance to win, according to the Grid. If Georgia secures a victory, it would add the Volunteers to the growing list of two-loss teams in the SEC. Will this be the moment Tennessee proves its mettle against a formidable opponent?

The Week 12 schedule is packed with exciting matchups involving teams from the AP Top 25. From the fierce rivalry games to pivotal conference clashes, there’s no shortage of drama.

Insights from PoolGenius

Throughout the 2024 season, Sporting News is collaborating with PoolGenius to offer top-notch pool strategy tips, expert quick picks, and updated data grids—all aimed at helping you emerge victorious. Not only does the PoolGenius college football data grid project winners for every game, but it also highlights the most significant discrepancies between its model and the betting public. This feature provides you with the opportunity to uncover hidden gems across the entire schedule.

Saturday, Nov. 16 Picks Against the Spread

  • No. 3 Texas (-15) at Arkansas (12 p.m., ABC)

The Razorbacks have struggled as home underdogs this season, going 1-2 against the spread (ATS), including some tough losses to LSU and Ole Miss. Texas, ranking second in the FBS for total defense, should give quarterback Quinn Ewers the support he needs after a stellar five-touchdown performance last week. With Arkansas allowing a staggering 694 total yards to Ole Miss, the Longhorns pose a serious threat.

Pick: Texas wins 41-20 and COVERS the spread.
PoolGenius pick: Texas

  • No. 25 Tulane (-6.5) at Navy (12 p.m., ESPN2)

Tulane’s offense has been explosive this season, averaging 41.0 points per game. Navy, having snapped a two-game losing streak, will look to make things interesting. This clash promises excitement as both teams vie for crucial victories.

Pick: Tulane wins 34-24 and COVERS the spread.
PoolGenius pick: Tulane

  • No. 2 Ohio State (-30.5) at Northwestern (12 p.m., BTN)

This matchup at Wrigley Field adds an intriguing twist to the Big Ten schedule. Northwestern’s offense has struggled, averaging just 19.2 points per game, which spells trouble against an Ohio State defense that ranks first in the FBS. Expect the Buckeyes to dominate.

Pick: Ohio State wins 38-7 and COVERS the spread.
PoolGenius pick: Ohio State

  • No. 13 Clemson (-10) at Pitt (12 p.m., ESPN)

Pitt has faced challenges recently, managing only 101 rushing yards per game over their last three outings. Clemson’s defense, allowing less than 100 yards in four of their last five games, will be a tough hurdle for the Panthers.

Pick: Clemson wins 31-24 but FAILS TO COVER the spread.
PoolGenius pick: Clemson

Exciting Evening Matchups

  • No. 1 Oregon (-14) at Wisconsin (7:30 p.m., NBC)

Oregon is looking to solidify its position in the Big Ten championship race. Wisconsin will aim to control the clock with their ground game, but can they keep up with the high-powered Ducks?

Pick: Oregon wins 34-17 and COVERS the spread.
PoolGenius pick: Oregon

  • No. 6 Tennessee at No. 11 Georgia (-9) (7:30 p.m., ABC)

Which Georgia team will show up? The one that crushed Texas, the one that dominated Florida, or the one that faltered against Ole Miss? Tennessee has yet to allow more than 19 points in a game this season, making this a must-watch matchup.

Pick: Georgia wins 26-21 but FAILS TO COVER the spread.
PoolGenius pick: Georgia

  • Kansas at No. 7 BYU (-3.5) (10:15 p.m., ESPN)

The Cougars have enjoyed a charmed season in Big 12 play, but Kansas is rejuvenated and ready to challenge. With a plus-10 turnover ratio, BYU has been effective, but can they handle a Jayhawks team that has shown resilience?

Pick: BYU wins 31-24 and COVERS the spread.
PoolGenius pick: BYU

As the excitement builds for Week 12, fans are gearing up for a thrilling day of college football. With so many pivotal games on the schedule, every matchup could have playoff implications. Will there be upsets? Only time will tell, but one thing is for sure: this weekend promises to deliver unforgettable moments on the gridiron!

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